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The Argyle Study

A Hyperhidrosis Research Study

Thank you so much for your interest in helping to further hyperhidrosis understanding.

We are currently looking for individuals with axillary hyperhidrosis (excessive sweating of the armpits) to participate in a clinical research study.

The clinical research study is evaluating the long term safety of an investigational study drug designed to treat axillary hyperhidrosis (excessive sweating of the armpits).  The study drug is a gel and is applied topically (on the skin) of the armpit.

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• Receiving study-related examinations by a Board Certified Dermatologist
• Receiving all study visits and study drugs at no cost
• Receiving compensation for time and travel


• This is an outpatient study (meaning you will not need to stay overnight at the doctor’s office) and is performed at a dermatologist’s clinic.

• The duration of the study will be 52 weeks (13 months) with 17 scheduled office visits.

• You will be compensated for completing these visits.


We are Looking for Participants Who:

Are male or female (not pregnant or breastfeeding)
Are 12 years of age or older
Have excessive sweat in the armpits

Study Timeline

What to Expect if You're Enrolled in the Argyle Study




Prequalify for the Argyle Study here.

Visit Site and Officially Enroll

Within A Couple of Weeks

Within a couple of weeks of you prequalifying, your study site will contact you to schedule an appointment. Then is when you'll come into their clinic, verify your eligibility, and officially enroll you in the Argle Study.

Begin Study And Download App

Week 1

Once you're officially enrolled, your site will send you home with a study product kit. Inside here will be your study product and study product application instructions. You'll also download the mobile app that has everything you need to know about participating in the Argyle Study as well as study product application reminders to keep yourself on track.

Nightly Study Product Application

Week 1-52

Each night, you'll apply the study product to your underarms.

Clinic Appointments

You'll come into your clinic a total of 17 times to check in and let your armpits enjoy some much deserved attention.

End of Study

Week 12

Collect your compensation. Since this is a clinical study, your individual results may vary.


People with hyperhidrosis can participate in the Argyle Study to help others, but also to receive a new potential treatment along with care and attention from the study staff. Clinical studies, like this one, offer hope for many people and a chance to help researchers find better treatments for others in the future.

– Dr. Stacy Smith, California Dermatology and Clinical Research Institute

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Frequently Asked Questions


What is a clinical study?

Clinical studies are any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions (study treatments) to evaluate the effects on health outcomes, such as whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain illnesses or groups of people.

What should I expect if I participate in this study?

During this clinical study, doctors, nurses, and other health care providers might be part of your study team. They will monitor your health closely. You may have more tests and medical exams than you would if you were not taking part in a clinical study. Your study team also may ask you to do other tasks. For example, you will have to apply a study drug at home, you fill out forms about how you feel, and you will be asked questions about the study treatment.

Who can participate in this clinical study?

Each clinical study defines who is eligible to take part in the study. Each trial must include only people who fit the patient traits for that study (the eligibility criteria). In this study, only people 18 years of age and older that experience focal hyperhidrosis in their armpits (excessive sweating) and meet other specific criteria can participate.

What are the possible benefits of participating in a clinical study?

Taking part in a clinical study can have many benefits. For example, you may gain access to a new treatment before it is widely available. If a new treatment is proven to work and you're in the group getting it, you might be among the first to benefit.

Even if you don't directly benefit from the results of the clinical study you take part in, the information gathered can help others by adding to scientific knowledge. People who take part in clinical studies are vital to the process of improving medical care. Many people volunteer because they want to help others.

What are the possible risks of participating in a clinical study?

Clinical studies do have risks and some downsides, such as the following:

• The new strategies and investigational treatments being studied aren't always better than other options available to you.
• Even if a new approach benefits some participants, it may not work for you.
• A new treatment may have side effects or risks that doctors don't know about or expect.

Will I be paid to participate?

Yes, you will be paid for your time volunteering in this clinical study.

What is a placebo?

A placebo is a substance that is not known to affect the underlying problem. It's usually an inert substance that is made to look exactly like the drug being tested, but without the drug. Placebos are used in studies in order to find out whether or not the pharmacological effect of a drug actually works or whether the effects produced by the drug might be related to psychological processes that are generically called the “placebo effect”.

Can a participant leave the clinical study at any point?

Yes, because your participation in a clinical study is always voluntary you may leave it at any time - either before the study starts or at any time during the study or the follow-up period.

What if I have more questions?

If you have more questions about hyperhidrosis, please visit our blog or the website of the International Hyperhidrosis Society (www.sweathelp.org).

For general questions about clinical studies, please visit www.clinicaltrials.gov.

For questions about this study, please first complete the Prequalification Questionnaire. If you are found to be a potential study candidate within one of the study site metropolitan areas, you will be directed to contact information for the site.